What is HOD?

So What is HOD?

 

HOD - Hypertrophic Osteodystrophy - in lay terms simply means "swollen joints"- so before your vet can treat this, we need to determine the cause - many things can cause swollen joints in a young growing puppy. Diagnosing HOD can be very difficult and confusing for your vet because several conditions can "mimic" the symptoms of HOD and they may not be familiar with that information. 

These are the things that can cause HOD- like symptoms:

Diet -a caloric dense diet and your dog is being over fed; intake vs output,and/or an imbalance in the diet due to addition of certain vitamin/minerals or human foods such as calcium tablets, meat, rice, cottage cheese. And/or a diet with no chelated minerals which means the body can't utilize these nutrients properly causing malabsorbtion of nutrients, either due to quality of macro-minerals or lack of micro-minerals in a diet, which are necessary for macro-minerals (Calcium/Phosphorus/Magnesium) to work properly. A dog can come down with HOD if you change dog food brands more than twice during delicate growth periods 10 - 16 weeks.

Blood infections - Septicemia/Septic-Arthritis - Have a blood test done immediately to rule out infection, this is by far more important than an x-ray. You already know the dog has swollen joints, if you have to make a choice between an xray and blood test due to financial reasons, a blood test is more important in ruling out infection. Keep in mind that pain alone can elevate the white cell count a little, it is significant elevated white cell counts that indicate infection. 

Editorial Comment:I NEVER recommend tapping a joint with a needle to check for infection, this is antiquated method. Once you break that seal in the joint area it is very vulnerable to staph infection in the joint, as well as early arthritis. 

Vaccine reactions - multivalent/combination vaccines are an enormous problem with young dogs with immature immune systems, especially if the dogs have not received adequate amounts of a antioxidants to help the body to detoxify from being bombarded with combination shots. It is even more of a problem when Lymes Vaccine or Rabies Vaccine has been at the same time as the combination shots. Rabies given before 6 months of age is not recommended for Great Danes (Purdue Vaccine Study) and should be given alone. In some states it means breaking the law if you follow this protocol. Discuss it with your vet first and if you are not comfortable with waiting until 6 months or older at least back up the system by using antioxidants (Vaccine Prevention Information).

Allergic reaction to certain antibiotics ( Sulfonamides or Cephalexin). Sulfonamides seem to be a problem for many Great Danes, Dobes, Goldens and perhaps other breeds. I do not recommend it's use unless this family of drugs is absolutely necessary (based on a blood culture) for a specific pathogenic bacteria.  Cephalexin on the other hand, although a good broad spectrum antibiotics, can also produce HOD like symptoms because it dries out the synovial fluid of the joints. My suggestion is to use something else if you have a choice and wait until more mature to use this drug. Adult dogs can have HOD like symptoms on Chephalexin as well. If you have to use this drug, use it with a watchful eye, and if the dog acts achy or lethargic, stop the use of the drug. 

*with permission - GDL.com

 Topics in Drug Therapy: Idiosyncratic Reactions to Sulfonamides in Dogs
Author: Alastair E. Cribb. DVM
JAVMA Vol.195, No.11 December 1, 1989
23 other reference articles named in this article. Some of the symptoms discussed are Polyarthritis and Fever, Hepatitis, Cutaneous Eruptions.

Drug-Associated Aplastic Anemia In Dogs
Author: D. Weiss, DVM, PhD and Jeff Klausner DVM, MS
JAVMA Vol 196. Now February 1, 1990
20 other reference articles named in this article.

Sulfadiazine-Induced Allergy in Six Doberman Pinschers
Author: U.Giger DVM, Linda Werner, DVM, N. Millichamp BVM, N Gorman Bvsc, PhD
JAVMA Vol 186, No. 5 March 1, 1985
50 other reference articles named in this article. Notes from summary: Treatment with sulfadiazine-trimethoprim caused serious, but reversible, allergic drug reactions 10-21 days after exposure. NON-SEPTIC POLY- ARTHRITIS was found in all dogs.

Trimethoprim-Sulfonamide-Associated Drug Eruptions in Dogs
Authors: L. Medleau, DVM, MS, K Shanley, DVM, P Rakich DVM, PhD, M. Goldschmidt, MSC, BVMS, MRCVS
Journal of the American Animal Hospital Association May/June 1990 Vol.26
20 other reference articles named in this article.

Aplastic Anemia Associated with Trimethoprim-Sulfadiazine and Fenbendazole Administration in the Dog
D. Weiss DVM Phd, L. Adams, DVM
JAVMA Vol 191. No 9 Nov. 1, 1987
7 other reference articles named in this article

Poly-Arthritis Associated with Sulfadiazine Administration
G. Lees, DVM, MS, K. Rogers, DVM, G. Troy DVM, MS
Dept. of Small Animal Medicine and Surgery, Texas A&M University, College of Veterinary Medicine. Southwestern Veterinarian Volume 37 No.1 1986
7 other reference articles named in this article. Quote: "The dogs discomfort, joint swelling and lameness became progressively worse throughout the day. The left hock was ultimately the worst swollen: this distended joint capsule protruded approximately a centimeter both medially and laterally. The dog could not stand without assistance. Dexamethasone was given intravenously and intramuscularly. The dog was noticeably improved by the next morning. Joint swelling was still prominent, but diminished."

Drug-Induced Immune Hypersensitivity Disorders in Two dogs Treated with Trimethoprim Sulfadiazine. (Non Septic PolyArthritis)
Author L. Werner DVM J. Bright DVM, MS
Journal of American Animal Hospital Association Sept/Oct 1983, Vol.19
7 other reference articles named in this article.